Methylfolate experiment

After getting the MTHFR testing back we began methylfolate and P5P. He had already been on methylcobalmin for months which was helpful. Initially he complained that after he took his Methylfolate/P5P supplement it always made him have to pee. I haven’t heard this complaint in a while so I think that stopped.

However, what we have noticed of lately, and it’s taken me some time to figure this out…is he is irritable an awful lot of the time. This is a fairly recent problem and we were attributing it to puberty initially but as I began thinking….even puberty isn’t this irritable!

Just not himself at all, argumentative, and didn’t want to do anything….even things he normally liked. He was obviously feeling bad and I couldn’t figure out why.

It dawned me on two days ago…what about the methylation supplements?!?!?

I did not respond well to methylfolate but he seemed just fine when we started it. So I assumed we were go to continue giving it to him. That was some 9 months ago but what if what’s good then isn’t good now?

I began searching the web and found an article by Ben Lynch describing the problems some people have with methylfolate. He talks about how someone could do well initially and then it can all fall apart.

So on a hunch I stopped giving his morning 800 mcg methyfolate supplement, just to see.

Guess what? He is back to himself!!

He is still taking his MB12 because he was on that prior to the methylfolate and did well on it for over a year.

His CBC is indicating he is no B12 anemic anymore…hmm..perhaps he doesn’t need as much folate?

The results of our LDN and antivirals

We had our follow-up with the doctor today to go over labs and touch base on progress after changes made in March following his lab results. This time we checked his thyroid levels, CBC with Diff, DHEA, Ferritin, Insulin, Comp Metabolic 14 Panel, thyroid antibodies.

Just to refresh what’s been going on this past few months we have been treating him for a viral and low immune system issue, hypothyroidism, anemia and nutritional deficiencies.

We were very pleased with the results because he is making progress! So that long list of antivirals and immune support he’s been taking daily since March has worked. His CBC with Diff is normal for the first time since 2011. His thyroid antibodies have come down to a normal range. Would be nice to see them even lower but from a diagnostic standpoint he no longer has “Hashimoto’s autoimmune hypothyroid”.

He is however, still hypothyroid on 1/2 grain of NatureThroid so we will be working to increase his dose slowly and repeating labs in a few months.

Ferritin came up nicely to 53 so we can cut back and phase out his iron supplement. Hopefully, he holds the levels, but if not, we might need to start it again.

DHEA is normal for his age now and ironically we never supplemented this. It isn’t really safe to use in children prior to the completion of puberty. All we did do was support his adrenal glands with adrenal cortex glandular, and give him thyroid hormone…that alone reduces the stress on the adrenal glands so they can make more DHEA!

I’m excited that our remaining supplement list is much lower now.

I also wanted to share that we have seen a significant reduction in anxiety and have been

Compounded Troches (Gummies) Image Credit: http://www.betterlivingmedical.com

able to reduce his theanine to once a day since raising thyroid meds. It is so amazing how adrenal symptoms are so often driven by low thyroid hormones and so easily corrected with a little thyroid hormone. We do need to finish out his Low dose naltrexone therapy for another 2 months though but he has no symptoms from taking it and doesn’t mind the gummies. (compounding pharmacies are a blessing, not on my wallet but eh..I’ll pick my battles!

I still have him on Citicholine for other reasons and I will continue reading about MTHFR because it my next post I talk about the problem we ran into with methylfolate.

Now we just hope these improvements stick off of the antivirals.

Thyroid Follow Up

The gains we had with starting treatment for hypothyroidism have slowly waned. Since he is only on a 1/4 grain, which is very low….I talked to my son’s doctor about increasing the dose. She agreed to raise to 1/2 grain. This is also still conservative.

One of the indicators I had to imply he needed an increase was that he wasn’t sleeping well at night again. This was a problem that went away when we started the 1/4 grain. He couldn’t fall asleep and if he somehow made it asleep by midnight, he was up at 3am for several hours.  He is a rather tricky fellow to figure out since he doesn’t have a lot of the normal symptoms you see in hypothyroidism. Rather what he has is a lot of adrenal stress from the low thyroid and not so great labs.

We go back for our follow-up this week so we can see his newest labs on 1/2 grain and also check the progress of the LDN therapy and antivirals. (fingers crossed those antibodies are gone and that CBC normalized)

What is nice to see is that he doesn’t need all that theanine for anxiety now. He reports he isn’t having anxiety now that he’s on thyroid medicine. I’ve seen this with my other child and many others. Sometimes the drain of low thyroid hormones on the adrenal glands is tremendous. I do also suspect methylfolate or P5P as contributors to a re-appearance in anxiety so we have discontinued that temporarily to see.

Wish us luck at our appointment! Fingers crossed we can stop antivirals….maybe