After getting the MTHFR testing back we began methylfolate and P5P. He had already been on methylcobalmin for probably a year which was helpful. Initially he complained that after he took his Methylfolate/P5P supplement it made him have to pee. I haven’t heard this complaint in a while so I think that stopped.
Lately he’s been really irritable, beyond what is normal for him. He’s just not himself at all. He’s been very argumentative and doesn’t want to do anything, even things he normally likes. He was obviously feeling bad and I couldn’t figure out why.
It dawned me on two days ago…what about the methylation supplements?!?!?
I did not respond well to methylfolate but he seemed just fine when we started it. So I assumed we were go to continue giving it to him. That was some 9 months ago but what if what’s good then isn’t good now? What if he had built up his levels and didn’t need it now?
I began searching the web and found an article by Ben Lynch describing the problems some people have with methylfolate. He talks about how someone could do well initially and then it can all fall apart later on.
So on a hunch I stopped giving his morning 800 mcg methyfolate supplement. Guess what? He is back to himself!!
He is still taking his MB12 because he was on that prior to the methylfolate and did well on it for over a year.
His CBC blood work is indicating he is not B12 anemic anymore…hmm..perhaps he doesn’t need as much folate like Ben said. Ben suggests that it might not need to given daily in some people. So we’ll take a break and then in a few months, give it just a few times a week at a lower dose.